Novel molecular imaging ligands targeting matrix metalloproteinases 2 and 9 for imaging of unstable atherosclerotic plaques.

Novel molecular imaging ligands targeting matrix metalloproteinases 2 and 9 for imaging of unstable atherosclerotic plaques.

Molecular imaging of matrix metalloproteinases (MMPs) may allow detection of atherosclerotic lesions vulnerable to rupture. In this study, we develop a novel radiolabelled compound that can target gelatinase MMP subtypes (MMP2/9) with high selectivity and inhibitory potency. Inhibitory potencies of...

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Bibliographic Details
Main Authors: Nazanin Hakimzadeh, Victorine A Pinas, Ger Molenaar, Vivian de Waard, Esther Lutgens, Berthe L F van Eck-Smit, Kora de Bruin, Jan J Piek, Jos L H Eersels, Jan Booij, Hein J Verberne, Albert D Windhorst
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5708805?pdf=render

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http://europepmc.org/articles/PMC5708805?pdf=render

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