Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile

Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile

Mitochondria are a major target for aging and are instrumental in the age-dependent deterioration of the human brain, but studying mitochondria in aging human neurons has been challenging. Direct fibroblast-to-induced neuron (iN) conversion yields functional neurons that retain important signs of ag...

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Bibliographic Details
Main Authors: Yongsung Kim, Xinde Zheng, Zoya Ansari, Mark C. Bunnell, Joseph R. Herdy, Larissa Traxler, Hyungjun Lee, Apua C.M. Paquola, Chrysanthi Blithikioti, Manching Ku, Johannes C.M. Schlachetzki, Jürgen Winkler, Frank Edenhofer, Christopher K. Glass, Andres A. Paucar, Baptiste N. Jaeger, Son Pham, Leah Boyer, Benjamin C. Campbell, Tony Hunter, Jerome Mertens, Fred H. Gage
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Cell Reports
Subjects:
mitochondria
aging
mitochondrial aging
directly converted induced neurons
glycolysis
oxidative phosphorylation
metabolic shift
neurodegenerative disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718307034

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http://www.sciencedirect.com/science/article/pii/S2211124718307034

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