Hypermethylation of WNT3A gene and non-syndromic cleft lip and/or palate in association with in utero exposure to lead: A mediation analysis

Objectives: We aim to investigate association between WNT3A methylation and risk of non-syndromic cleft lip and/or palate (NSCL/P), and examine mediating effect of WNT3A methylation on the association of NSCL/P and lead (Pb) exposure in fetuses. Methods: DNA methylation of WNT3A in umbilical cord bl...

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Bibliographic Details
Main Authors: Wenlei Yang, Yingnan Guo, Wenli Ni, Tian Tian, Lei Jin, Jufen Liu, Zhiwen Li, Aiguo Ren, Linlin Wang
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651320312525