Maternal high-fat diet exaggerates diet-induced insulin resistance in adult offspring by enhancing inflammasome activation through noncanonical pathway of caspase-11

Maternal high-fat diet exaggerates diet-induced insulin resistance in adult offspring by enhancing inflammasome activation through noncanonical pathway of caspase-11

Objective: Maternal high-fat diet (HFD) has been shown to promote the development of insulin resistance (IR) in adult offspring; however, the underlying mechanisms remain unclear. Methods: Eight-week-old female wild-type mice (C57BL/6) were fed either an HFD or a normal diet (ND), one week prior to...

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Bibliographic Details
Main Authors: Naotoshi Wada, Hiroyuki Yamada, Shinichiro Motoyama, Makoto Saburi, Takeshi Sugimoto, Hiroshi Kubota, Daisuke Miyawaki, Noriyuki Wakana, Daisuke Kami, Takehiro Ogata, Satoaki Matoba
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Molecular Metabolism
Subjects:
Maternal high-fat diet
Insulin resistance
Inflammasome
Interleukin-1β
Caspase-1
Caspase-11
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820300624

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http://www.sciencedirect.com/science/article/pii/S2212877820300624

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