Targeted induction of endoplasmic reticulum stress induces cartilage pathology.

Targeted induction of endoplasmic reticulum stress induces cartilage pathology.

Pathologies caused by mutations in extracellular matrix proteins are generally considered to result from the synthesis of extracellular matrices that are defective. Mutations in type X collagen cause metaphyseal chondrodysplasia type Schmid (MCDS), a disorder characterised by dwarfism and an expande...

Full description

Bibliographic Details
Main Authors: M Helen Rajpar, Ben McDermott, Louise Kung, Rachel Eardley, Lynette Knowles, Mel Heeran, David J Thornton, Richard Wilson, John F Bateman, Richard Poulsom, Peter Arvan, Karl E Kadler, Michael D Briggs, Raymond P Boot-Handford
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-10-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2757901?pdf=render

Internet

http://europepmc.org/articles/PMC2757901?pdf=render

Similar Items