Molecular modeling on the identification of potential Janus Kinase 3 (JAK3) inhibitor based on the Indonesian Medicinal Plant Database

Molecular modeling on the identification of potential Janus Kinase 3 (JAK3) inhibitor based on the Indonesian Medicinal Plant Database

The Janus tyrosine kinases (JAKs) have shown great promise as therapeutic protein targets in the treatment of cancer and inflammation diseases. This study used pharmacophore modeling to identify potential inhibitors of Janus kinase 3 (JAK3). A pharmacophore model was developed based on a known JAK3...

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Bibliographic Details
Main Authors: Muhammad Arba, Sanang Nur Safitri, Andry Nur Hidayat, Arry Yanuar, Muhammad Sulaiman Zubair, Asmiyenti Djaliasrin Djalil, Daryono Hadi Tjahjono
Format: Article
Language:English
Published: ITB Journal Publisher 2020-12-01
Series:Journal of Mathematical and Fundamental Sciences
Subjects:
Janus kinase
MM-PBSA
molecular dynamics simulation
pharmacophore modeling
virtual screening
Online Access:https://journals.itb.ac.id/index.php/jmfs/article/view/12588

Internet

https://journals.itb.ac.id/index.php/jmfs/article/view/12588

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