A low-dose β1-blocker in combination with milrinone improves intracellular Ca2+ handling in failing cardiomyocytes by inhibition of milrinone-induced diastolic Ca2+ leakage from the sarcoplasmic reticulum.

A low-dose β1-blocker in combination with milrinone improves intracellular Ca2+ handling in failing cardiomyocytes by inhibition of milrinone-induced diastolic Ca2+ leakage from the sarcoplasmic reticulum.

OBJECTIVES:The purpose of this study was to investigate whether adding a low-dose β1-blocker to milrinone improves cardiac function in failing cardiomyocytes and the underlying cardioprotective mechanism. BACKGROUND:The molecular mechanism underlying how the combination of low-dose β1-blocker and mi...

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Bibliographic Details
Main Authors: Shigeki Kobayashi, Takehisa Susa, Hironori Ishiguchi, Takeki Myoren, Wakako Murakami, Takayoshi Kato, Masakazu Fukuda, Akihiro Hino, Takeshi Suetomi, Makoto Ono, Hitoshi Uchinoumi, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Masahiro Doi, Takeshi Yamamoto, Masafumi Yano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4304815?pdf=render

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http://europepmc.org/articles/PMC4304815?pdf=render

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