Quantitative phosphoproteomic analysis identifies the potential therapeutic target EphA2 for overcoming sorafenib resistance in hepatocellular carcinoma cells

Liver cancer: A new route to fighting drug resistance Inhibiting the activity of a protein known as EphA2 may help overcome the development of drug resistance during treatment of hepatocellular carcinoma, the most common form of liver cancer. Resistance often develops to sorafenib, the main drug tre...

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Bibliographic Details
Main Authors: Chih-Ta Chen, Li-Zhu Liao, Ching-Hui Lu, Yung-Hsuan Huang, Yu-Kie Lin, Jung-Hsin Lin, Lu-Ping Chow
Format: Article
Language:English
Published: Nature Publishing Group 2020-03-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-020-0404-2