Poor Long-Term Efficacy of Prevnar-13 in Sickle Cell Disease Mice Is Associated with an Inability to Sustain Pneumococcal-Specific Antibody Titers.

Poor Long-Term Efficacy of Prevnar-13 in Sickle Cell Disease Mice Is Associated with an Inability to Sustain Pneumococcal-Specific Antibody Titers.

One of the most common causes of morbidity and mortality in children with sickle cell disease (SCD) is infection with the pneumococcal bacterium (Streptococcus pneumoniae). Unfortunately, the polysaccharide-conjugate vaccine appears to be less effective in individuals with SCD when compared to the g...

Full description

Bibliographic Details
Main Authors: Steven M Szczepanek, Sean Roberts, Kara Rogers, Christina Cotte, Alexander J Adami, Sonali J Bracken, Sharon Salmon, Eric R Secor, Roger S Thrall, Biree Andemariam, Dennis W Metzger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4766082?pdf=render

Internet

http://europepmc.org/articles/PMC4766082?pdf=render

Similar Items