α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner

α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner

Alpha-synuclein (αS) misfolding is associated with Parkinson's disease (PD) but little is known about the mechanisms underlying αS toxicity. Increasing evidence suggests that defects in membrane transport play an important role in neuronal dysfunction. Here we demonstrate that the GTPase Rab8a...

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Bibliographic Details
Main Authors: Guowei Yin, Tomas Lopes da Fonseca, Sibylle E. Eisbach, Ane Martín Anduaga, Carlo Breda, Maria L. Orcellet, Éva M. Szegő, Patricia Guerreiro, Diana F. Lázaro, Gerhard H. Braus, Claudio O. Fernandez, Christian Griesinger, Stefan Becker, Roger S. Goody, Aymelt Itzen, Flaviano Giorgini, Tiago F. Outeiro, Markus Zweckstetter
Format: Article
Language:English
Published: Elsevier 2014-10-01
Series:Neurobiology of Disease
Subjects:
α-Synuclein
Aggregation
Parkinson's disease
Phosphorylation
Rab GTPase
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611400182X

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http://www.sciencedirect.com/science/article/pii/S096999611400182X

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