α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner
Alpha-synuclein (αS) misfolding is associated with Parkinson's disease (PD) but little is known about the mechanisms underlying αS toxicity. Increasing evidence suggests that defects in membrane transport play an important role in neuronal dysfunction. Here we demonstrate that the GTPase Rab8a...
Main Authors: | Guowei Yin, Tomas Lopes da Fonseca, Sibylle E. Eisbach, Ane Martín Anduaga, Carlo Breda, Maria L. Orcellet, Éva M. Szegő, Patricia Guerreiro, Diana F. Lázaro, Gerhard H. Braus, Claudio O. Fernandez, Christian Griesinger, Stefan Becker, Roger S. Goody, Aymelt Itzen, Flaviano Giorgini, Tiago F. Outeiro, Markus Zweckstetter |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2014-10-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S096999611400182X |
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