B Cell Depletion Eliminates FVIII Memory B Cells and Enhances AAV8-coF8 Immune Tolerance Induction When Combined With Rapamycin

B Cell Depletion Eliminates FVIII Memory B Cells and Enhances AAV8-coF8 Immune Tolerance Induction When Combined With Rapamycin

Hemophilia A is an inherited coagulation disorder resulting in the loss of functional clotting factor VIII (FVIII). Presently, the most effective treatment is prophylactic protein replacement therapy. However, this requires frequent life-long intravenous infusions of plasma derived or recombinant cl...

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Bibliographic Details
Main Authors: Moanaro Biswas, Brett Palaschak, Sandeep R. P. Kumar, Jyoti Rana, David M. Markusic
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
hemophilia A
inhibitors
gene therapy
AAV
anti-CD20
rapamycin
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01293/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01293/full

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