Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk
Chromosomal abnormalities such as 11q deletion are associated with poor prognosis in neuroblastoma. Here, the authors perform a genome-wide association study and identify an association between a variant within a Matrix metalloproteinase (MMP) gene member, MMP20, and 11q-deletion subtype neuroblasto...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2017-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00408-8 |
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doaj-7488eacd07eb497cac82b43d8ef8c81f2021-05-11T07:06:19ZengNature Publishing GroupNature Communications2041-17232017-09-01811710.1038/s41467-017-00408-8Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma riskXiao Chang0Yan Zhao1Cuiping Hou2Joseph Glessner3Lee McDaniel4Maura A. Diamond5Kelly Thomas6Jin Li7Zhi Wei8Yichuan Liu9Yiran Guo10Frank D. Mentch11Haijun Qiu12Cecilia Kim13Perry Evans14Zalman Vaksman15Sharon J. Diskin16Edward F. Attiyeh17Patrick Sleiman18John M. Maris19Hakon Hakonarson20The Center for Applied Genomics, Children’s Hospital of PhiladelphiaThe Center for Applied Genomics, Children’s Hospital of PhiladelphiaThe Center for Applied Genomics, Children’s Hospital of PhiladelphiaThe Center for Applied Genomics, Children’s Hospital of PhiladelphiaDivision of Oncology and Center for Childhood Cancer Research, The Children’s Hospital of PhiladelphiaDivision of Oncology and Center for Childhood Cancer Research, The Children’s Hospital of PhiladelphiaThe Center for Applied Genomics, Children’s Hospital of PhiladelphiaThe Center for Applied Genomics, Children’s Hospital of PhiladelphiaDepartment of Computer Science, New Jersey Institute of TechnologyThe Center for Applied Genomics, Children’s Hospital of PhiladelphiaThe Center for Applied Genomics, Children’s Hospital of PhiladelphiaThe Center for Applied Genomics, Children’s Hospital of PhiladelphiaThe Center for Applied Genomics, Children’s Hospital of PhiladelphiaThe Center for Applied Genomics, Children’s Hospital of PhiladelphiaDivision of Oncology and Center for Childhood Cancer Research, The Children’s Hospital of PhiladelphiaDivision of Oncology and Center for Childhood Cancer Research, The Children’s Hospital of PhiladelphiaDivision of Oncology and Center for Childhood Cancer Research, The Children’s Hospital of PhiladelphiaDivision of Oncology and Center for Childhood Cancer Research, The Children’s Hospital of PhiladelphiaThe Center for Applied Genomics, Children’s Hospital of PhiladelphiaDivision of Oncology and Center for Childhood Cancer Research, The Children’s Hospital of PhiladelphiaThe Center for Applied Genomics, Children’s Hospital of PhiladelphiaChromosomal abnormalities such as 11q deletion are associated with poor prognosis in neuroblastoma. Here, the authors perform a genome-wide association study and identify an association between a variant within a Matrix metalloproteinase (MMP) gene member, MMP20, and 11q-deletion subtype neuroblastoma.https://doi.org/10.1038/s41467-017-00408-8 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Xiao Chang Yan Zhao Cuiping Hou Joseph Glessner Lee McDaniel Maura A. Diamond Kelly Thomas Jin Li Zhi Wei Yichuan Liu Yiran Guo Frank D. Mentch Haijun Qiu Cecilia Kim Perry Evans Zalman Vaksman Sharon J. Diskin Edward F. Attiyeh Patrick Sleiman John M. Maris Hakon Hakonarson |
| spellingShingle |
Xiao Chang Yan Zhao Cuiping Hou Joseph Glessner Lee McDaniel Maura A. Diamond Kelly Thomas Jin Li Zhi Wei Yichuan Liu Yiran Guo Frank D. Mentch Haijun Qiu Cecilia Kim Perry Evans Zalman Vaksman Sharon J. Diskin Edward F. Attiyeh Patrick Sleiman John M. Maris Hakon Hakonarson Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk Nature Communications |
| author_facet |
Xiao Chang Yan Zhao Cuiping Hou Joseph Glessner Lee McDaniel Maura A. Diamond Kelly Thomas Jin Li Zhi Wei Yichuan Liu Yiran Guo Frank D. Mentch Haijun Qiu Cecilia Kim Perry Evans Zalman Vaksman Sharon J. Diskin Edward F. Attiyeh Patrick Sleiman John M. Maris Hakon Hakonarson |
| author_sort |
Xiao Chang |
| title |
Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk |
| title_short |
Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk |
| title_full |
Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk |
| title_fullStr |
Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk |
| title_full_unstemmed |
Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk |
| title_sort |
common variants in mmp20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-09-01 |
| description |
Chromosomal abnormalities such as 11q deletion are associated with poor prognosis in neuroblastoma. Here, the authors perform a genome-wide association study and identify an association between a variant within a Matrix metalloproteinase (MMP) gene member, MMP20, and 11q-deletion subtype neuroblastoma. |
| url |
https://doi.org/10.1038/s41467-017-00408-8 |
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