Mutant IDH and non-mutant chondrosarcomas display distinct cellular metabolomes

Mutant IDH and non-mutant chondrosarcomas display distinct cellular metabolomes

Abstract Background Majority of chondrosarcomas are associated with a number of genetic alterations, including somatic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 genes, but the downstream effects of these mutated enzymes on cellular metabolism and tumor energetics are unknown. As IDH mu...

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Bibliographic Details
Main Authors: Sinthu Pathmanapan, Olga Ilkayeva, John T. Martin, Adrian Kwan Ho Loe, Hongyuan Zhang, Guo-Fang Zhang, Christopher B. Newgard, Jay S. Wunder, Benjamin A. Alman
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Cancer & Metabolism
Subjects:
Chondrosarcoma
Metabolism
Mutant IDH
Cancer
Genetic mutation
Amino acids
Online Access:https://doi.org/10.1186/s40170-021-00247-8

Internet

https://doi.org/10.1186/s40170-021-00247-8

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