Alendronate prevents angiotensin II-induced collagen I production through geranylgeranylation-dependent RhoA/Rho kinase activation in cardiac fibroblasts

Alendronate prevents angiotensin II-induced collagen I production through geranylgeranylation-dependent RhoA/Rho kinase activation in cardiac fibroblasts

Collagen I is the main component of extracellular matrix in cardiac fibrosis. Our previous studies have reported inhibition of farnesylpyrophosphate synthase prevents angiotensin II-induced cardiac fibrosis, while the exact molecular mechanism was still unclear. This paper was designed to investigat...

Full description

Bibliographic Details
Main Authors: Yang Ye, Xue Lv, Mei-hui Wang, Jun Zhu, Shi-quan Chen, Chen-yang Jiang, Guo-sheng Fu
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Journal of Pharmacological Sciences
Subjects:
Alendronate
Collagen I
Geranylgeranylation
RhoA
Rho kinase
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861315002108

Internet

http://www.sciencedirect.com/science/article/pii/S1347861315002108

Similar Items