Sugar Matters: Improving In Vivo Clearance Rate of Highly Glycosylated Recombinant Plasma Proteins for Therapeutic Use

Sugar Matters: Improving In Vivo Clearance Rate of Highly Glycosylated Recombinant Plasma Proteins for Therapeutic Use

Correct glycosylation of proteins is essential for production of therapeutic proteins as glycosylation is important for protein solubility, stability, half-life and immunogenicity. The heavily glycosylated plasma protein C1-inhibitor (C1-INH) is used in treatment of hereditary angioedema attacks. In...

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Bibliographic Details
Main Authors: Sacha Zeerleder, Ruchira Engel, Tao Zhang, Dorina Roem, Gerard van Mierlo, Ineke Wagenaar-Bos, Sija Marieke van Ham, Manfred Wuhrer, Diana Wouters, Ilse Jongerius
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Pharmaceuticals
Subjects:
C1-inhibitor
glycosylation
recombinant protein
Online Access:https://www.mdpi.com/1424-8247/14/1/54

Internet

https://www.mdpi.com/1424-8247/14/1/54

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