Cerebrospinal Fluid Aβ43 Is Reduced in Early-Onset Compared to Late-Onset Alzheimer’s Disease, But Has Similar Diagnostic Accuracy to Aβ42

Cerebrospinal Fluid Aβ43 Is Reduced in Early-Onset Compared to Late-Onset Alzheimer’s Disease, But Has Similar Diagnostic Accuracy to Aβ42

Background: Amyloid beta 1–43 (Aβ43) may be a useful additional biomarker for diagnosing Alzheimer’s disease (AD). We have investigated cerebrospinal fluid (CSF) levels of Aβ43 in patients with early-onset AD in contrast to levels in late-onset AD. For comparison, in addition to the ‘core’ biomarker...

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Bibliographic Details
Main Authors: Camilla Lauridsen, Sigrid B. Sando, Ina Møller, Guro Berge, Precious K. Pomary, Gøril R. Grøntvedt, Øyvind Salvesen, Geir Bråthen, Linda R. White
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
early-onset Alzheimer’s disease
biomarkers
tau
YKL-40
neurofilament light
glial fibrillary acidic protein
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2017.00210/full

Internet

http://journal.frontiersin.org/article/10.3389/fnagi.2017.00210/full

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