Universality of J-Shaped and U-Shaped Dose-Response Relations as Emergent Properties of Stochastic Transition Systems
Dose-response data for many chemical carcinogens exhibit multiple apparent concentration thresholds. A relatively small increase in exposure concentration near such a threshold disproportionately increases incidence of a specific tumor type. Yet, many common mathematical models of carcinogenesis do...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2005-07-01
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| Series: | Dose-Response |
| Online Access: | https://doi.org/10.2203/dose-response.0003.03.006 |