A replicating modified vaccinia tiantan strain expressing an avian-derived influenza H5N1 hemagglutinin induce broadly neutralizing antibodies and cross-clade protective immunity in mice.

A replicating modified vaccinia tiantan strain expressing an avian-derived influenza H5N1 hemagglutinin induce broadly neutralizing antibodies and cross-clade protective immunity in mice.

To combat the possibility of a zoonotic H5N1 pandemic in a timely fashion, it is necessary to develop a vaccine that would confer protection against homologous and heterologous human H5N1 influenza viruses. Using a replicating modified vaccinia virus Tian Tan strain (MVTT) as a vaccine vector, we co...

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Bibliographic Details
Main Authors: Haixia Xiao, Li Liu, Qingyu Zhu, Zhiwu Tan, Wenbo Yu, Xian Tang, Dawei Zhan, Yanhua Du, Haibo Wang, Di Liu, Zhixin Li, Kwok-Yung Yuen, David D Ho, George F Gao, Zhiwei Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3866202?pdf=render

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http://europepmc.org/articles/PMC3866202?pdf=render

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