Development of a Transcriptional Amplification System Based on the PEG3 Promoter to Target Androgen Receptor-Positive and -Negative Prostate Cancer Cells

Development of a Transcriptional Amplification System Based on the PEG3 Promoter to Target Androgen Receptor-Positive and -Negative Prostate Cancer Cells

Localized prostate cancer (PCa) is often curable, whereas metastatic disease treated by castration inevitably progresses toward castration-resistant PCa (CRPC). Most CRPC treatments target androgen receptor (AR) signaling. However, not all CRPC cells rely on AR activity for survival and proliferatio...

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Bibliographic Details
Main Authors: Pallavi Jain, Pier-Luc Clermont, Francis Desmeules, Amina Zoubeidi, Bertrand Neveu, Frédéric Pouliot
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
prostate cancer
neuroendocrine prostate cancer (NEPC)
progression elevated gene-3 (PEG3) promoter
castration-resistant prostate cancer (CRPC)
bioluminescence
Online Access:http://www.mdpi.com/1422-0067/20/1/216

Internet

http://www.mdpi.com/1422-0067/20/1/216

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