Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy

Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy

Background/Aims: the anti-vascular endothelial growth factors (VEGF), Aflibercept and Ranibizumab, are used for the treatment of macular degeneration. Here we examined the involvement of nitric oxide (NO), mitochondria function and of apoptosis/autophagy in their antioxidant effects in human retinal...

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Bibliographic Details
Main Authors: Stefano De Cillà, Serena Farruggio, Stela Vujosevic, Giulia Raina, Davide Filippini, Valentina Gatti, Nausicaa Clemente, David Mary, Diego Vezzola, Giamberto Casini, Luca Rossetti, Elena Grossini
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Cell viability
Mitochondria
Peroxidation
Anti-VEGF
Online Access:http://www.karger.com/Article/FullText/479441

Internet

http://www.karger.com/Article/FullText/479441

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