The Enigmatic Role of TP53 in Germ Cell Tumours: Are We Missing Something?

The Enigmatic Role of TP53 in Germ Cell Tumours: Are We Missing Something?

The cure rate of germ cell tumours (GCTs) has significantly increased from the late 1970s since the introduction of cisplatin-based therapy, which to date remains the milestone for GCTs treatment. The exquisite cisplatin sensitivity has been mainly explained by the over-expression in GCTs of wild-ty...

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Bibliographic Details
Main Authors: Margaret Ottaviano, Emilio Francesco Giunta, Pasquale Rescigno, Ricardo Pereira Mestre, Laura Marandino, Marianna Tortora, Vittorio Riccio, Sara Parola, Milena Casula, Panagiotis Paliogiannis, Antonio Cossu, Ursula Maria Vogl, Davide Bosso, Mario Rosanova, Brunello Mazzola, Bruno Daniele, Giuseppe Palmieri, Giovannella Palmieri
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
germ cell tumour
testicular cancer
TP53
thyroid cancer
Li-Fraumeni syndrome
somatic mutations
Online Access:https://www.mdpi.com/1422-0067/22/13/7160

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https://www.mdpi.com/1422-0067/22/13/7160

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