Non-full-length Water-Soluble CXCR4QTY and CCR5QTY Chemokine Receptors: Implication for Overlooked Truncated but Functional Membrane Receptors

Non-full-length Water-Soluble CXCR4QTY and CCR5QTY Chemokine Receptors: Implication for Overlooked Truncated but Functional Membrane Receptors

Summary: It was posited that functionalities of GPCRs require full-length sequences that are negated by residue deletions. Here we report that significantly truncated nfCCR5QTY and nfCXCR4QTY still bind native ligands. Receptor-ligand interactions were discovered from yeast 2-hybrid screening and co...

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Bibliographic Details
Main Authors: Rui Qing, Fei Tao, Pranam Chatterjee, Gaojie Yang, Qiuyi Han, Haeyoon Chung, Jun Ni, Bernhard P. Suter, Jan Kubicek, Barbara Maertens, Thomas Schubert, Camron Blackburn, Shuguang Zhang
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:iScience
Subjects:
Molecular Biology
Cell Biology
Structural Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220308622

Internet

http://www.sciencedirect.com/science/article/pii/S2589004220308622

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