RNA-Seq mapping and detection of gene fusions with a suffix array algorithm.

RNA-Seq mapping and detection of gene fusions with a suffix array algorithm.

High-throughput RNA sequencing enables quantification of transcripts (both known and novel), exon/exon junctions and fusions of exons from different genes. Discovery of gene fusions-particularly those expressed with low abundance- is a challenge with short- and medium-length sequencing reads. To add...

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Bibliographic Details
Main Authors: Onur Sakarya, Heinz Breu, Milan Radovich, Yongzhi Chen, Yulei N Wang, Catalin Barbacioru, Sowmi Utiramerur, Penn P Whitley, Joel P Brockman, Paolo Vatta, Zheng Zhang, Liviu Popescu, Matthew W Muller, Vidya Kudlingar, Nriti Garg, Chieh-Yuan Li, Benjamin S Kong, John P Bodeau, Robert C Nutter, Jian Gu, Kelli S Bramlett, Jeffrey K Ichikawa, Fiona C Hyland, Asim S Siddiqui
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3320572?pdf=render

Internet

http://europepmc.org/articles/PMC3320572?pdf=render

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