Sublethal doxorubicin promotes migration and invasion of breast cancer cells: role of Src Family non-receptor tyrosine kinases

Abstract Background Doxorubicin (Dox) is a widely used chemotherapy, but its effectiveness is limited by dose-dependent side effects. Although lower Dox doses reduce this risk, studies have reported higher recurrence of local disease with no improvement in survival rate in patients receiving low dos...

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Bibliographic Details
Main Authors: Samia Mohammed, Achraf A. Shamseddine, Benjamin Newcomb, Ronald S. Chavez, Tyler D. Panzner, Allen H. Lee, Daniel Canals, Chioma M. Okeoma, Christopher J. Clarke, Yusuf A. Hannun
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Breast Cancer Research
Subjects:
Fyn
Yes
p53
ATR
Online Access:https://doi.org/10.1186/s13058-021-01452-5