Ghrelin Pre-treatment Attenuates Local Oxidative Stress and End Organ Damage During Cardiopulmonary Bypass in Anesthetized Rats

Ghrelin Pre-treatment Attenuates Local Oxidative Stress and End Organ Damage During Cardiopulmonary Bypass in Anesthetized Rats

Cardiopulmonary bypass (CPB) induced systemic inflammation significantly contributes to the development of postoperative complications, including respiratory failure, myocardial, renal and neurological dysfunction and ultimately can lead to failure of multiple organs. Ghrelin is a small endogenous p...

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Bibliographic Details
Main Authors: Vijayakumar Sukumaran, Hirotsugu Tsuchimochi, Yutaka Fujii, Hiroshi Hosoda, Kenji Kangawa, Tsuyoshi Akiyama, Mikiyasu Shirai, Eisuke Tatsumi, James T. Pearson
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Physiology
Subjects:
ghrelin
inflammation
organ damage
oxidative stress
cardiopulmonary bypass
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00196/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2018.00196/full

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