The impact of metallothionein-II on microglial response to tumor necrosis factor-alpha (TNFα) and downstream effects on neuronal regeneration

The impact of metallothionein-II on microglial response to tumor necrosis factor-alpha (TNFα) and downstream effects on neuronal regeneration

Abstract Background The extracellular environment plays an important role in supporting the regeneration of axons after injury. Metallothionein-II (MTII) is a metal-binding protein known for its neuroprotective effect by directly stimulating the growth of axons after injury. Previous studies have sh...

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Bibliographic Details
Main Authors: Jacqueline Y. K. Leung, William R. Bennett, Anna E. King, Roger S. Chung
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Journal of Neuroinflammation
Subjects:
Metallothionein
Microglia
Low-density lipoprotein receptor-related protein-1
Low-density lipoprotein receptor-related protein-2
Axon regeneration
Traumatic brain injury
Online Access:http://link.springer.com/article/10.1186/s12974-018-1070-3

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http://link.springer.com/article/10.1186/s12974-018-1070-3

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