T‐type calcium channel blockade induces apoptosis in C2C12 myotubes and skeletal muscle via endoplasmic reticulum stress activation

T‐type calcium channel blockade induces apoptosis in C2C12 myotubes and skeletal muscle via endoplasmic reticulum stress activation

Loss of T‐type calcium channel (TCC) function has been reported to result in decreased cell viability and impaired muscle regeneration, but the underlying mechanisms remain largely unknown. We previously found that expression of TCC is reduced in aged pelvic floor muscle of multiple vaginal delivery...

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Bibliographic Details
Main Authors: Mao Chen, Suting Li, Menglei Hao, Jue Chen, Zhihan Zhao, Shasha Hong, Jie Min, Jianming Tang, Ming Hu, Li Hong
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:FEBS Open Bio
Subjects:
apoptosis
endoplasmic reticulum stress
skeletal muscle wasting
T‐type calcium channel
Online Access:https://doi.org/10.1002/2211-5463.12965

Internet

https://doi.org/10.1002/2211-5463.12965

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