Cadmium induces CCL2 production in glioblastoma cells via activation of MAPK, PI3K, and PKC pathways

Cadmium induces CCL2 production in glioblastoma cells via activation of MAPK, PI3K, and PKC pathways

Cadmium (Cd) is accumulated in human astrocytes and induces the production of interleukin (IL)-6 and IL-8. Astrocytes are one of the major sources of chemokine C–C motif ligand 2 (CCL2; known as monocyte chemoattractant protein-1 [MCP-1]), in the brain. Elevated CCL2 levels are associated with cogni...

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Bibliographic Details
Main Authors: Thitima Kasemsuk, Suttinee Phuagkhaopong, Ruedeemars Yubolphan, Norapat Rungreangplangkool, Pornpun Vivithanaporn
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Journal of Immunotoxicology
Subjects:
cadmium
glioblastoma
ccl2
mcp-1
mapk
pi3k
akt
pkc
Online Access:http://dx.doi.org/10.1080/1547691X.2020.1829211

Internet

http://dx.doi.org/10.1080/1547691X.2020.1829211

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