Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability

Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability

Thrombospondin 4 has been shown to protect the heart and the skeletal muscle by enhancing matrix secretion and membrane stability thanks to its intracellular function. Here the authors show that thrombospondin 3 exacerbates injury-induced cardiomyopathy and promotes destabilization of the cardiomyoc...

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Bibliographic Details
Main Authors: Tobias G. Schips, Davy Vanhoutte, Alexander Vo, Robert N. Correll, Matthew J. Brody, Hadi Khalil, Jason Karch, Andoria Tjondrokoesoemo, Michelle A. Sargent, Marjorie Maillet, Robert S. Ross, Jeffery D. Molkentin
Format: Article
Language:English
Published: Nature Publishing Group 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-08026-8

Internet

https://doi.org/10.1038/s41467-018-08026-8

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