Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node
Tumor neoantigens can be drained to the lymph nodes, but the nature and the significance of the induced immune responses are still unclear. Here the authors use a mouse genetic tumor model to show that tumor-specific CD4 T cells can become anergic or suppressive in the draining lymph node to modulat...
Main Authors: | , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-05-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-04524-x |