Arylsulfonylamino-Benzanilides as Inhibitors of the Apical Sodium-Dependent Bile Salt Transporter (SLC10A2)

Arylsulfonylamino-Benzanilides as Inhibitors of the Apical Sodium-Dependent Bile Salt Transporter (SLC10A2)

The apical sodium-dependent bile salt transporter (ASBT) plays a pivotal role in maintaining bile acid homeostasis. Inhibition of ASBT would reduce bile acid pool size and lower cholesterol levels. In this report, a series of novel arylsulfonylaminobenzanilides were designed and synthesized as poten...

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Bibliographic Details
Main Authors: Rong-Guang Shao, Shi-Ying Cai, Chang-Liang Xu, Ju-Xian Wang, Xiao-Guang Bai, Hong-Wei He, Hong-Tao Liu, Yu-Cheng Wang
Format: Article
Language:English
Published: MDPI AG 2013-06-01
Series:Molecules
Subjects:
ASBT inhibitors
bile acids
arylsulfonylaminobenzanilides
cholesterol lowering drug
Online Access:http://www.mdpi.com/1420-3049/18/6/6883

Internet

http://www.mdpi.com/1420-3049/18/6/6883

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