Caffeic Acid Phenethyl Ester Suppresses Proliferation and Survival of TW2.6 Human Oral Cancer Cells via Inhibition of Akt Signaling

Caffeic Acid Phenethyl Ester Suppresses Proliferation and Survival of TW2.6 Human Oral Cancer Cells via Inhibition of Akt Signaling

Caffeic acid phenethyl ester (CAPE) is a bioactive component extracted from honeybee hive propolis. Our observations indicated that CAPE treatment suppressed cell proliferation and colony formation of TW2.6 human oral squamous cell carcinoma (OSCC) cells dose-dependently. CAPE treatment decreased G1...

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Bibliographic Details
Main Authors: Chih-Pin Chuu, Ya-Wen Chen, Horng-Dar Wang, Jang-Yang Chang, Hung-Che Chiang, Chi-Jung Chung, Ping-Hsuan Hsiao, Jonathan Yang, Liang-Cheng Su, Ying-Yu Kuo, Chieh Huo, Hui-Ping Lin
Format: Article
Language:English
Published: MDPI AG 2013-04-01
Series:International Journal of Molecular Sciences
Subjects:
oral cancer
caffeic acid phenethyl ester
TW2.6
cell proliferation
cell cycle
Akt
Akt1
Akt2
phospho-Akt Ser473
phospho-Akt Thr 308
FOXO1
FOXO3a
phospho-FOXO1 Thr24
phospho-FoxO3a Thr32
NF-κB
phospho-NF-κB Ser536
Rb
phospho-Rb Ser807/811
Skp2
cyclin D1
p27
5-fluorouracil
Online Access:http://www.mdpi.com/1422-0067/14/5/8801

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http://www.mdpi.com/1422-0067/14/5/8801

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