Activity and Mechanism of Antimicrobial Peptide-Mimetic Amphiphilic Polymethacrylate Derivatives

Activity and Mechanism of Antimicrobial Peptide-Mimetic Amphiphilic Polymethacrylate Derivatives

Cationic amphiphilic polymethacrylate derivatives (PMAs) have shown potential as a novel class of synthetic antimicrobials. A panel of PMAs with varied ratios of hydrophobic and cationic side chains were synthesized and tested for antimicrobial activity and mechanism of action. The PMAs are shown to...

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Bibliographic Details
Main Authors: Kenichi Kuroda, Gregory A. Caputo, Philomene Mpiga, Michael Urban, Iva Sovadinova, Edmund F. Palermo
Format: Article
Language:English
Published: MDPI AG 2011-09-01
Series:Polymers
Subjects:
antimicrobials
amphiphilic polymers
host-defense peptides
antibiotic resistance
Online Access:http://www.mdpi.com/2073-4360/3/3/1512/

Internet

http://www.mdpi.com/2073-4360/3/3/1512/

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