Selective Janus Kinase 1 Inhibition Is a Promising Therapeutic Approach for Lupus Erythematosus Skin Lesions

Selective Janus Kinase 1 Inhibition Is a Promising Therapeutic Approach for Lupus Erythematosus Skin Lesions

BackgroundCutaneous lupus erythematosus (CLE) is an interferon (IFN) -driven autoimmune skin disease characterized by an extensive cytotoxic lesional inflammation with activation of different innate immune pathways. Aim of our study was to investigate the specific role of Janus kinase 1 (JAK1) activ...

Full description

Bibliographic Details
Main Authors: Tanja Fetter, Paul Smith, Tugce Guel, Christine Braegelmann, Thomas Bieber, Joerg Wenzel
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
lupus erythematosus
skin
kinase inhibitor
innate immunity
interferon
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00344/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00344/full

Similar Items