Comparative Studies on Multi-Component Pharmacokinetics of Polygonum multiflorum Thunb Extract After Oral Administration in Different Rat Models

Comparative Studies on Multi-Component Pharmacokinetics of Polygonum multiflorum Thunb Extract After Oral Administration in Different Rat Models

The clinical use of Polygonum multiflorum Thunb (PM) has been restricted or banned in many countries, due to its hepatotoxic adverse effects. Its toxicity research has become a hot topic. So far, the pharmacokinetic studies of PM, focusing on prototype compounds such as 2,3,5,4'-tetrahydroxysti...

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Bibliographic Details
Main Authors: Ninghui Ma, Yong Zhang, Liyan Sun, Yuan Zhao, Yue Ding, Tong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
ANIT
CCl4
pharmacokinetics
bilirubin metabolism enzyme
metabolic transporter
polygonum multiflorum thunb
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.655332/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.655332/full

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