DYRK1A Negatively Regulates CDK5-SOX2 Pathway and Self-Renewal of Glioblastoma Stem Cells

DYRK1A Negatively Regulates CDK5-SOX2 Pathway and Self-Renewal of Glioblastoma Stem Cells

Glioblastoma display vast cellular heterogeneity, with glioblastoma stem cells (GSCs) at the apex. The critical role of GSCs in tumour growth and resistance to therapy highlights the need to delineate mechanisms that control stemness and differentiation potential of GSC. Dual-specificity tyrosine ph...

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Bibliographic Details
Main Authors: Brianna Chen, Dylan McCuaig-Walton, Sean Tan, Andrew P. Montgomery, Bryan W. Day, Michael Kassiou, Lenka Munoz, Ariadna Recasens
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
glioblastoma
cancer stem cells
DYRK1A
CDK5
SOX2
bone morphogenetic protein 4 (BMP4)
Online Access:https://www.mdpi.com/1422-0067/22/8/4011

Internet

https://www.mdpi.com/1422-0067/22/8/4011

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