Delta1 expression, cell cycle exit, and commitment to a specific secretory fate coincide within a few hours in the mouse intestinal stem cell system.

Delta1 expression, cell cycle exit, and commitment to a specific secretory fate coincide within a few hours in the mouse intestinal stem cell system.

The stem cells of the small intestine are multipotent: they give rise, via transit-amplifying cell divisions, to large numbers of columnar absorptive cells mixed with much smaller numbers of three different classes of secretory cells--mucus-secreting goblet cells, hormone-secreting enteroendocrine c...

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Bibliographic Details
Main Authors: Despina Stamataki, Maxine Holder, Christine Hodgetts, Rosemary Jeffery, Emma Nye, Bradley Spencer-Dene, Douglas J Winton, Julian Lewis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3168508?pdf=render

Internet

http://europepmc.org/articles/PMC3168508?pdf=render

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