Mutational burden and potential oligogenic model of TBX6‐mediated genes in congenital scoliosis

Mutational burden and potential oligogenic model of TBX6‐mediated genes in congenital scoliosis

Abstract Background Congenital scoliosis (CS) is a spinal deformity due to vertebral malformations. Although insufficiency of TBX6 dosage contributes to a substantial proportion of CS, the molecular etiology for the majority of CS remains largely unknown. TBX6‐mediated genes involved in the process...

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Bibliographic Details
Main Authors: Yang Yang, Sen Zhao, Yuanqiang Zhang, Shengru Wang, Jiashen Shao, Bowen Liu, Yaqi Li, Zihui Yan, Yuchen Niu, Xiaoxin Li, Lianlei Wang, Yongyu Ye, Xisheng Weng, Zhihong Wu, Deciphering Disorders Involving Scoliosis and COmorbidities (DISCO) study, Jianguo Zhang, Nan Wu
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
congenital scoliosis
exome sequencing
mutational burden
TBX6‐mediated genes
Online Access:https://doi.org/10.1002/mgg3.1453

Internet

https://doi.org/10.1002/mgg3.1453

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