Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation

Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation

Abstract Background Dysfunction in survival and differentiation of osteoblasts commonly occurs in patients with osteoporosis. Cannabinoid receptor type 2 (CNR2) is a major receptor of endocannabinoid system that is crucial for bone mass homeostasis. Our group prior demonstrated that activation of CN...

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Bibliographic Details
Main Authors: Aihua Xu, Yang Yang, Yang Shao, Meng Wu, Yongxin Sun
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Cell Communication and Signaling
Subjects:
Osteoporosis
Osteoblast
CNR2
Autophagy
p62
Nrf2 signaling pathway
Online Access:https://doi.org/10.1186/s12964-020-0512-6

Internet

https://doi.org/10.1186/s12964-020-0512-6

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