CD38 is methylated in prostate cancer and regulates extracellular NAD+

CD38 is methylated in prostate cancer and regulates extracellular NAD+

Abstract Background Cancer cell metabolism requires sustained pools of intracellular nicotinamide adenine dinucleotide (NAD+) which is maintained by a balance of NAD+ hydrolase activity and NAD+ salvage activity. We recently reported that human prostate cancer can be initiated following oncogene exp...

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Bibliographic Details
Main Authors: Jack Mottahedeh, Michael C. Haffner, Tristan R. Grogan, Takao Hashimoto, Preston D. Crowell, Himisha Beltran, Andrea Sboner, Rohan Bareja, David Esopi, William B. Isaacs, Srinivasan Yegnasubramanian, Matthew B. Rettig, David A. Elashoff, Elizabeth A. Platz, Angelo M. De Marzo, Michael A. Teitell, Andrew S. Goldstein
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Cancer & Metabolism
Subjects:
Prostate
CD38
NAD+
Methylation
Online Access:http://link.springer.com/article/10.1186/s40170-018-0186-3

Internet

http://link.springer.com/article/10.1186/s40170-018-0186-3

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