Low expression of NSD1, NSD2, and NSD3 define a subset of human papillomavirus-positive oral squamous carcinomas with unfavorable prognosis

Low expression of NSD1, NSD2, and NSD3 define a subset of human papillomavirus-positive oral squamous carcinomas with unfavorable prognosis

Abstract Background Frequent mutations in the nuclear receptor binding SET domain protein 1 (NSD1) gene have been observed in head and neck squamous cell carcinomas (HNSCC). NSD1 encodes a histone 3 lysine-36 methyltransferase. NSD1 mutations are correlated with improved clinical outcomes and increa...

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Bibliographic Details
Main Authors: Steven F. Gameiro, Farhad Ghasemi, Peter Y. F. Zeng, Neil Mundi, Christopher J. Howlett, Paul Plantinga, John W. Barrett, Anthony C. Nichols, Joe S. Mymryk
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Infectious Agents and Cancer
Subjects:
Head and neck cancer
Head and neck squamous cell carcinoma
HPV
WHSC1
WHSC1L1
Epigenetics
Online Access:https://doi.org/10.1186/s13027-021-00347-6

Internet

https://doi.org/10.1186/s13027-021-00347-6

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