In Vivo TLR9 Inhibition Attenuates CpG-Induced Myocardial Dysfunction

The involvement of toll-like receptor 9 (TLR9), a receptor for bacterial DNA, in septic cardiac depression has not been clarified in vivo. Thus, the aim of the study was to test possible TLR9 inhibitors (H154-thioate, IRS954-thioate, and chloroquine) for their ability to protect the cardiovascular s...

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Bibliographic Details
Main Authors: O. Boehm, P. Markowski, M. van der Giet, V. Gielen, A. Kokalova, C. Brill, A. Hoeft, G. Baumgarten, R. Meyer, P. Knuefermann
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2013/217297