PARP Inhibitors Talazoparib and Niraparib Sensitize Melanoma Cells to Ionizing Radiation

PARP Inhibitors Talazoparib and Niraparib Sensitize Melanoma Cells to Ionizing Radiation

(1) Background: Niraparib and Talazoparib are poly (ADP-ribose) polymerase (PARP) 1/2 inhibitors. It is assumed that combining PARP inhibitors with radiotherapy could be beneficial for cancer treatment. In this study, melanoma cells were treated with Niraparib and Talazoparib in combination with ion...

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Bibliographic Details
Main Authors: Stephanie Jonuscheit, Tina Jost, Fritzi Gajdošová, Maximilian Wrobel, Markus Hecht, Rainer Fietkau, Luitpold Distel
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Genes
Subjects:
PARP
kinase inhibitors
ionizing radiation
Online Access:https://www.mdpi.com/2073-4425/12/6/849

Internet

https://www.mdpi.com/2073-4425/12/6/849

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