Mitophagy promotes sorafenib resistance through hypoxia-inducible ATAD3A dependent Axis

Mitophagy promotes sorafenib resistance through hypoxia-inducible ATAD3A dependent Axis

Abstract Background The identification of novel targets for recovering sorafenib resistance is pivotal for Hepatocellular carcinoma (HCC) patients. Mitophagy is the programmed degradation of mitochondria, and is likely involved in drug resistance of cancer cells. Here, we identified hyperactivated m...

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Bibliographic Details
Main Authors: Hong Wu, Tao Wang, Yiqiang Liu, Xin Li, Senlin Xu, Changtao Wu, Hongbo Zou, Mianfu Cao, Guoxiang Jin, Jinyi Lang, Bin Wang, Baohua Liu, Xiaolin Luo, Chuan Xu
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Mitophagy
ATAD3A
Hypoxia
Sorafenib resistance
Online Access:https://doi.org/10.1186/s13046-020-01768-8

Internet

https://doi.org/10.1186/s13046-020-01768-8

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