Utility of cfDNA Fragmentation Patterns in Designing the Liquid Biopsy Profiling Panels to Improve Their Sensitivity

Utility of cfDNA Fragmentation Patterns in Designing the Liquid Biopsy Profiling Panels to Improve Their Sensitivity

Genotyping of cell-free DNA (cfDNA) in plasma samples has the potential to allow for a noninvasive assessment of tumor biology, avoiding the inherent shortcomings of tissue biopsy. Next generation sequencing (NGS), a leading technology for liquid biopsy analysis, continues to be hurdled with several...

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Bibliographic Details
Main Authors: Maxim Ivanov, Polina Chernenko, Valery Breder, Konstantin Laktionov, Ekaterina Rozhavskaya, Sergey Musienko, Ancha Baranova, Vladislav Mileyko
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Genetics
Subjects:
NGS
cfDNA
liquid biopsy
cancer
DNA fragmentation
nucleosome
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00194/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00194/full

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