Natural Aromatic Compounds as Scaffolds to Develop Selective G-Quadruplex Ligands: From Previously Reported Berberine Derivatives to New Palmatine Analogues

Natural Aromatic Compounds as Scaffolds to Develop Selective G-Quadruplex Ligands: From Previously Reported Berberine Derivatives to New Palmatine Analogues

In this paper, the selective interactions of synthetic derivatives of two natural compounds, berberine and palmatine, with DNA G-quadruplex structures were reported. In particular, the previous works on this subject concerning berberine were further presented and discussed, whereas the results conce...

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Bibliographic Details
Main Authors: Marco Franceschin, Lorenzo Cianni, Massimo Pitorri, Emanuela Micheli, Stefano Cacchione, Claudio Frezza, Mauro Serafini, Ming-Hao Hu, Huafi Su, Zhishu Huang, Lianquan Gu, Armandodoriano Bianco
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Molecules
Subjects:
G-quadruplex DNA
interactions
berberine and palmatine derivatives
NMR
FRET and MST assays
Online Access:http://www.mdpi.com/1420-3049/23/6/1423

Internet

http://www.mdpi.com/1420-3049/23/6/1423

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