SOCS3 Promotes ALV-J Virus Replication via Inhibiting JAK2/STAT3 Phosphorylation During Infection

SOCS3 Promotes ALV-J Virus Replication via Inhibiting JAK2/STAT3 Phosphorylation During Infection

Avian leukosis virus subgroup J (ALV-J) is an oncogenic retrovirus that causes immunosuppression and neoplastic diseases in poultry. Cytokine signal-transduction inhibitor molecule 3 (SOCS3) is an important negative regulator of the JAK2/STAT3 signaling pathway and plays certain roles in ALV-J infec...

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Bibliographic Details
Main Authors: Guodong Mo, Huali Fu, Bowen Hu, Qihong Zhang, Mingjian Xian, Zihao Zhang, Ling Lin, Meiqing Shi, Qinghua Nie, Xiquan Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
ALV-J
chicken
immune
JAK2/STAT3
SOCS3
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.748795/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2021.748795/full

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