Mycobacteria induce TPL-2 mediated IL-10 in IL-4-generated alternatively activated macrophages.

Mycobacteria induce TPL-2 mediated IL-10 in IL-4-generated alternatively activated macrophages.

IL-4 drives expansion of Th2 cells that cause generation of alternatively activated macrophages (AAMs). Filarial infections are established early in life, induce increased IL-4 production are co-endemic with tuberculosis (TB). We sought to understand, therefore, how mycobacteria are handled in the c...

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Bibliographic Details
Main Authors: Soumya Chatterjee, Kawsar R Talaat, Emily E van Seventer, Carl G Feng, Alan L Scott, Anne Jedlicka, Amanda Dziedzic, Thomas B Nutman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5489173?pdf=render

Internet

http://europepmc.org/articles/PMC5489173?pdf=render

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