A mechanism for suppression of the CDP-choline pathway during apoptosis

A mechanism for suppression of the CDP-choline pathway during apoptosis

Inhibition of the CDP-choline pathway during apoptosis restricts the availability of phosphatidylcholine (PtdCho) for assembly of membranes and synthesis of signaling factors. The N-terminal nuclear localization signal (NLS) in CTP:phosphocholine cytidylyltransferase (CCT)α is removed during apoptos...

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Bibliographic Details
Main Authors: Craig C. Morton, Adam J. Aitchison, Karsten Gehrig, Neale D. Ridgway
Format: Article
Language:English
Published: Elsevier 2013-12-01
Series:Journal of Lipid Research
Subjects:
CTP:phosphocholine cytidylyltransferase
phosphatidylcholine
choline transporter
caspase 3
RNA interference
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520356893

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http://www.sciencedirect.com/science/article/pii/S0022227520356893

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